Synthetic nanovaccines for immunotherapy

Nanovaccines for Cancer Immunotherapy

There are three major types of therapeutic approaches currently available to combat cancer, namely chemotherapy (which utilises small molecule agents to destroy cancer cells), radiotherapy (radio labelled small molecules) and immunotherapy. The immunotherapy is the oldest among them, which dates back to the discovery of a surgeon known as William B. Coley in 1891, who has treated his patients w...

Targeted nanovaccines against respiratory pathogens

Immunotherapy for Breast Cancer Treatment

Breast cancer, as a heterogeneous disease, includes a wide range of pathological and clinical behaviors. Current treatment protocols, including radiotherapy, chemotherapy, and hormone replacement therapy, are mainly associated with poor response and high rate of recurrence. Therefore, more efforts are needed to develop alternative therapies for this type of cancer. Immunotherapy, as a novel str...

Engulfing tumors with synthetic extracellular matrices for cancer immunotherapy.

Local immunotherapies are under investigation for the treatment of unresectable tumors and sites of solid tumor resection to prevent local recurrence. Successful local therapy could also theoretically elicit systemic immune responses against cancer. Here we explored the delivery of therapeutic dendritic cells (DCs), cytokines, or other immunostimulatory factors to tumors via the use of 'self-ge...

Synthetic IgE peptide vaccine for immunotherapy of allergy.

An immunotherapeutic vaccine for allergy was produced by designing IgE-based synthetic peptide immunogens and selecting them for functional immunogenicity. The vaccine targets the binding site on IgE for the high affinity receptor Fc epsilon RI, by active immunization. The peptide target site on IgE heavy chain was selected from among the amino acid sequences for the C epsilon 2, C epsilon 3, a...